Type of Medication: Antibiotic
Indications: Aerobic and anerobic Gram Postive bacteria including mulri-resistant staphylococci i.e MRSA.
Side Effects: Rash, pruritus, fever,bronchospasm, rigors, urticaria, angiodema, anaphylaxis, nausea, vomiting, diarrhoea,blood disorders including eosinophilia, leucopenia, neutropenia, thrombocytopenia, thrombocytosis, increase of serum transaminases or alk phos, transient elevation of creatinine, dizziness, headache.eosinophilia, hearing loss.
Route of administration: Adult (Intravenous)
Dose:400mg iv 12 hourly for 3 doses then 400mg iv or im daily for severe infections. 400mg iv or im on day 1 then 200mg iv or im daily for moderate infections
Administration: Reconstitute 200mg or 400mg vial with water for injection provided.Administer either im, iv bolus, or iv infusion over 30 mins diluted with 50ml NaCl 0.9% or Dextrose 5%.
Route of administration: Paediatric (Intravenous)
Dose:10 mg/kg 12 hrly for first 3 doses then once daily. Can be increased to 15 mg/kg in severe infection. Max: as for adult.
Administration: Reconstitute 200mg or 400mg vial with water for injection then administer either im, iv bolus, or iv infusion over 30 mins diluted with 50ml NaCl 0.9%. Plasma level monitoring not necessary but can be used in paeds to optimise treatment.
Examples of some Drug Interactions
Interacting drug: Nephrotoxic drugs – additive nephrotoxicity
Interacting drug: Ototoxic drugs