Type of Medication: Antiemetic
Indications: Prevention and treatment of nausea and vomiting. Improving gut motility and reducing nausea during overnight NG or gastrostomy feeding.
Side Effects: Rash, drowsiness; dry mouth, malaise, extrapyramidal side effects, galactorrhoea, gynaecomastia, reduced libido, increased prolactin levels, amenorrhoea, anxiety, breast pain, diarrhoea, galactorrhoea, pruritus, amenorrhoea, convulsions, nervousness, oculogyric crisis, QT-interval prolongation, sudden cardiac death, urinary retention, ventricular arrhythmias
Route of administration: Adult (Oral)
Dose:10mg tds, or increase up to maximum of 20mg every 4 hours
Administration: Avaliable as 10 mg tablets or 5 mg/5 ml suspension
Route of administration: Adult (Rectal)
Dose:30-60 mg every 4-8 hours
Examples of some Drug Interactions
Interacting drug: Dicyclomine
antagonise effect on GI activity
Interacting drug: Opioid analgesics
antagonise effect on GI
Interacting drugs: Drugs which increase QT interval
Domperidone increases the risk of QT-prolongation when given with drugs such as clarithromycin.