Type of Medication: Antiemetic

Indications: Prevention and treatment of nausea and vomiting. Improving gut motility and reducing nausea during overnight NG or gastrostomy feeding.

Side Effects: Rash, drowsiness; dry mouth,  malaise, extrapyramidal side effects, galactorrhoea, gynaecomastia, reduced libido, increased prolactin levels, amenorrhoea, anxiety,  breast pain, diarrhoea,  galactorrhoea,  pruritus, amenorrhoea,  convulsions, nervousness, oculogyric crisis,  QT-interval prolongation,  sudden cardiac death,  urinary retention, ventricular arrhythmias

Route of administration: Adult (Oral)

Dose:10mg tds, or increase up to maximum of 20mg every 4 hours

Administration: Avaliable as 10 mg tablets or 5 mg/5 ml suspension

Route of administration: Adult (Rectal)

Dose:30-60 mg every 4-8 hours

Examples of some Drug Interactions

Interacting drug: Dicyclomine

antagonise effect on GI activity

Interacting drug: Opioid analgesics

antagonise effect on GI

Interacting drugs: Drugs which increase QT interval

Domperidone increases the risk of QT-prolongation when given with drugs such as clarithromycin.