Type of Medication: Antibiotic

Indications: Treatment of Pseudomonas aeruginosa and Burkholderia respiratory infections (covers H. influenzae)

Side Effects:  Rash, pruritus, eosinophilia, increase in PT time, thrombocytopenia, neutropenia, jaundice, hepatitis, transient elevations of hepatic transaminases and alk phos, diarrhoea, nausea, mouth ulcers, altered taste. Reduce dose in renal failure, anaemia,vaginitis, candidiasis, hypotension, weakness, confusion, vertigo, sweating, headaches, halitosis, headaches, fever, malaise, sneezing.

Route of administration: Adult (Intravenous)

Dose: 2.5 grams tds

Administration: Reconstitute vials to 10ml with water then either dilute to 50ml with NaCl 0.9% and infuse over 30 minutes, or inject the 10ml as a bolus over 3 minutes.

Route of administration: Paediatric (Intravenous)

Dose:200-250 mg/kg/day in 3 divided doses. Max: 8 grams/day.


Examples of Drug Interactions

Interacting drug: Warfarin

may increase INR