Ceftazidime + avibactam

Type of Medication: Antibiotic

Indications: Treatment of Pseudomonas aeruginosa and Burkholderia cepacia complex infections

Side Effects: Abdominal discomfort; agranulocytosis; allergic reactions; anaphylaxis; aplastic anaemia; blood disorders; confusion; diarrhoea; disturbances in liver enzymes; dizziness; eosinophilia; haemolytic anaemia; hallucinations; headache; hyperactivity; hypertonia; leucopenia; nausea; nervousness; pruritus; rashes; reversible interstitial nephritis; serum sickness-like reactions with rashes, fever and arthralgia; sleep disturbances; Stevens-Johnson syndrome; thrombocytopenia; toxic epidermal necrolysis; transient cholestatic jaundice; transient hepatitis; urticaria; vomiting

Route of administration: Adult (Intravenous)

Dose Ceftazidime/avibactam – 2/0.5 g every 8 hours

Administration: Manufacturer advises for intravenous infusion (Zavicefta®) give in Glucose 5%, or Sodium Chloride 0.9%, or Sodium Chloride 0.45% with Glucose 2.5% combination or Lactated Ringer’s solution. Reconstitute each 2 g/0.5 g vial with 10 mL water for injections; dilute requisite dose in an appropriate infusion bag and give over 120 minutes.