Type of Medication: Antibiotic
Indications: Treatment of urinary and respiratory infections caused by sensitive organisms
Side Effects: Side Effects: GI upset including nausea and vomiting, pruritus, rash, hyperkaleamia, depression of haematopoiesis. Rarley erythema multiforme, toxic epidermal necrolysis, photosensitivity and other allergic reactions includong angioedema and anaphylaxis. Aseptic meningitis and uveitis have been reported.
Route of administration: Route of administration: Adult (Oral)
Route of administration: Paediatric (Oral)
Dose:8 mg/kg/day in 2 divided doses
Administration: Maximum dose of 200 mg bd
Examples of some Drug Interactions
Interacting drug: Cyclosporin
increased risk of nephrotoxicity. ? Reduced cyclosporin concentration
Interacting drug: Dapsone
plasma level of both drugs increased.
Interacting drug: Methotrexate
antifolate effect increased, increased risk of haematological toxicity.
Interacting drug: Phenytoin
level of phenytoin increased
Interacting drug: Procainamide
increased concentrations of procainamide
Interacting drug: Repaglinide
? enhances hypoglycaemic effcet avoid concomitant use.
Interacting drug: Warfarin
? anticoagulation effect enhanced