Type of Medication: Antibiotic

Indications: Treatment and prophylaxis of Staphyloccocus aureus infection

Side Effects: Nausea, diarrhoea, rash, neutropenia, thrombocytopenia, hepatitis, cholestatic jaundice, hypersensitivity, angiodema, convulsions with high intravenous doses in renal failure

Route of administration: Adult (Intravenous)

Dose:500 to 1000mg qds

Administration: Add to 100 ml 5% dextrose or 0.9% saline and administer over 30 to 60 minutes. Can be given as a bolus in 5-10 ml water for injection over 3-5 min.

Route of administration: Adult (Oral)

Dose Treatment doe 1g to 2g QDS. (50 to 100 mg / kg / day in 3 to 4 divided doses). Prophylaxis
1g BD (can increase to 2g BD).

Route of administration: Paediatric (Intravenous)

Dose:50-100 mg/kg in 4 divided doses up to 1g qds


Route of administration: Paediatric (Oral)

Dose: 3-5kg: 125mg bd,  5-9kg: 175mg bd, 9-15kg: 250mg bd, Older children: 25 mg/kg bd (usual max 1 gm bd). 50 to 100 mg/kg/day in 3 to 4 divided doses. Given bd sometimes for compliance. (Normal dose 500-1000mg 4 times a day).

Give 1 hour BEFORE meals or on an empty stomach.

Examples of some Drug Interactions