Type of Medication: CFTR Potentiator

Indications: Treatment of Class III, IV and residual function CFTR mutations

Side Effects: Abdominal pain; diarrhoea; dizziness; ear discomfort; headache; nasal congestion; nasopharyngitis; oropharyngeal pain; pharyngeal erythema; pharyngeal oedema; rash; rhinitis; tinnitus; upper respiratory-tract infection; Gynaecomastia; nipple disorders; vestibular disorder

Route of administration: Adult (Oral)

150 mg every 12 hours.

Manufacturer advises reduce dose to 150 mg twice a week with concurrent use of potent inhibitors of CYP3A4.

Manufacturer advises reduce dose to 150 mg once daily with concurrent use of moderate inhibitors of CYP3A4.

Examples of some Drug Interactions

Food and lifestyle

Avoid bitter (Seville) oranges as they are predicted to increase the exposure to ivacaftor.