Type of Medication: Bile acid sequestrant
Indications: Pruritus associated with partial biliary obstruction. Primary biliary cirrhosis. Contra-indicated in complete biliary obstruction. Various other indications not relating to cystic fibrosis.
Side Effects: As drug is not absorbed gastro-intestinal side effects predominate.Constipation is common but diarrhoea, nausea, vomiting and abdo pain have also occurred. May exacerbate vitamin K deficiency, rarely hyperchloraemic acidosis with prolonged use. Intestinal obstruction reported rarely.
Route of administration: Adult (Oral)
Dose:4 to 8 g daily as a single or multiple dose.
Administration: With at least 150ml of water or other suitable fluid such as fruit juice or thin soups. Available as sugar free sachets.
Route of administration: Paediatric (Oral)
Dose:1 month to 1 year: 1g once daily, adjusted according to response. Max 9g daily. — 1 to 6 years: 2g once daily, adjusted according to response. Max 18g daily. — 12 to 18 years: see adults.
Administration: see adult (oral)
Examples of some Drug Interactions
All oral medication
Other drugs should be taken at least 1 hour before or 4-6 hours after cholestyramine to reduce possible interference with absorption