Pancreatin

Type of Medication: Pancreatic enzyme

Indications: Pancreatic enzyme replacement

Side Effects: Nausea, vomiting, abdominal discomfort, diarrhoea, constipation; hyperuricosuria and hyperuricaemia have been associated with very high doses. Perioral skin and buccal irritation can occur if preperations retained in mouth. Excessive doses can cause perianal irritation.High strength enzymes such as Nutrizym 22 and Pancrease HL have been associated with large bowel strictures. Try and avoid > 10,000 units lipase/kg daily.

Route of administration: Adult (Oral)

Dose:Granules : 5-10g just before meals wash down or mixed with liquid.

Administration: Granuels providing minimum of : protease 300 units, lipase 5000 units, amylase 4000 per gram.

Route of administration: Adult (Oral)

Dose:Tablets e/c ( protease 110 units, lipase 1900 units, amylase 1700 units): 5- 10 tablets before meals.

Administration: Adjust dose accordingly. Refer to dietitian

Route of administration: Adult (Oral)

Dose:Tablets forte e/c ( protease 330 units, lipase 5,500 units, amylase 5,000 units); 6-10 tablets before meals.

Administration: Adjust dose accordingly. Refer to dietitian.

Route of administration: Adult (Oral)

Dose:Capsules ( protease 430 units, lipase 8000 units, amylase 9000 units): 2 -6 capsules with meals. Adjust dose accordingly . Refer to dietician

Administration: Spread enzymes by taking some before and during meal.

Route of administration: Adult (Oral)

Dose:Powder ( protease 1,400 units, lipase 25,000 units, amylase 30,000 units per gram): 0.5 – 2 grams with meals washed down or mixed with liquid.

Administration: Adjust dose accordingly

Route of administration: Paediatric (Oral)

Dose:Granules : 5-10g just before meals wash down or mixed with liquid

Examples of some Drug Interactions