Type of Medication: Antibiotic
Indications: Treatment of community acquired upper and lower respiratory tract infections. Treatment of pulmonary infections including due to bacteria such as Haemophilus influenzae, Staphylococcus aureus and Moraxella catarrhalis
Side Effects: Nausea, diarrhoea, rash, colitis, hepatitis, cholestatic jaundice (risk 6 times greater than with amoxicillin alone), erythema multiforme, vasculitis, prolonged bleeding time, fits, phlebitis, vaginal itching and discharge, transient blood dyscrasias, superficial staining of teeth with suspension.
Route of administration: Adult (Intravenous)
Dose:1.2 g every 8 hours. Frequency can be increased to every 6 hours in serious infections.
Route of administration: Adult (Oral)
Dose:375 mg tds, may be doubled in severe infections to 625 mg tds.
Route of administration: Paediatric (Intravenous)
Dose:3 months-12 years: 30 mg/kg every eight hours. In more serious infections, increase frequency to every six hours. 0-3 months: 30 mg/kg every 12 hours in premature infants and in full-term infants during the perinatal period, increasing to eight hours thereafter.
Route of administration: Paediatric (Oral)
Dose:25 mg/kg/day in divided doses every eight hours. In more serious infections the dosage may be increased up to 50 mg/kg/day in divided doses every eight hours.
Administration: Under 1 year: 25 mg/kg/day, for example a 7.5 kg child would require 2 ml Augmentin 125/31 SF Suspension t.d.s. 1-6 years:(10-18 kg) 5ml Augmentin 125/31 SF Suspension t.d.s. Over 6 years (18-40 kg): 5ml Augmentin 250/62 SF Suspension t.d.s.Tablets are not recommended for children under 12 years
Examples of some Drug Interactions
nteracting drug: Allopurinol
increased risk of rash
Interacting drug: Methotrexate
reduced excretion of methotrexate
Interacting drug: Probenecid
reduces excretion of penicillins