Pancreatin (Nutrizym)

Type of Medication: Pancreatic enzyme

Indications: Pancreatic enzyme replacement

Side Effects: Nausea, vomiting, abdominal discomfort, diarrhoea, constipation; hyperuricosuria and hyperuricaemia have been associated with very high doses. Perioral skin and buccal irritation can occur if preperations retained in mouth. Excessive doses can cause perianal irritation.High strength enzymes such as Nutrizym 22 and Pancrease HL have been associated with large bowel strictures. Try and avoid > 10,000 units lipase/kg daily. Nutryzim GR has been associated with fibrosing colonopathy as well as the high strength preparations. .

Route of administration: Adult (Oral)

Dose:Nutrizym 10: Start at 1 to 2 with meal. Aim to keep < 10,000 units lipase/Kg. (500 units protease, 10,000 units lipase, 9,000 units amylase per capsule)

Administration: Spread enzymes by taking some just before and during meal. Remember to take enzymes with fat containing snacks and to adjust according to fat content of food. Refer to dietitian

Route of administration: Adult (Oral)

Dose:Nutrizym 22: as above but would not advise in new patient.(1,100 units protease, 22,000 units lipase, 19,800 units amylase per capsule)


Examples of some Drug Interactions