Type of Medication: Leukotriene receptor antagonist

Indications: Prophylaxis of exercise induced asthma, adjunct therapy in the treatment of asthma. Possible effect in CF

Side Effects: GI disturbances, dry mouth, thirst, hypersensitivity reactions, asthenia, dizziness, agitation, restlessness, paraesthesia, headaches, sleep disorders, URTI, fever, arthralgia, palpitations, increased bleeding tendency, cholestatic hepatitis, oedema, hallucinations and seizures also reported.

Route of administration: Adult (Oral)

Dose:10 mg od

Administration: At bedtime with or without food

Route of administration: Paediatric (Oral)

Dose:6 months – 5 years 4 mg in the evening: 6-14 yrs 5 mg nocte.

Administration: If with food take 1 hr before or 2 hr after. 4 mg granules – may be swallowed or mixed with cold food (but not fluid) and taken immediately

Examples of some Drug Interactions