Type of Medication: Leukotriene receptor antagonist
Indications: Prophylaxis of exercise induced asthma, adjunct therapy in the treatment of asthma. Possible effect in CF
Side Effects: GI disturbances, dry mouth, thirst, hypersensitivity reactions, asthenia, dizziness, agitation, restlessness, paraesthesia, headaches, sleep disorders, URTI, fever, arthralgia, palpitations, increased bleeding tendency, cholestatic hepatitis, oedema, hallucinations and seizures also reported.
Route of administration: Adult (Oral)
Dose:10 mg od
Administration: At bedtime with or without food
Route of administration: Paediatric (Oral)
Dose:6 months – 5 years 4 mg in the evening: 6-14 yrs 5 mg nocte.
Administration: If with food take 1 hr before or 2 hr after. 4 mg granules – may be swallowed or mixed with cold food (but not fluid) and taken immediately
Examples of some Drug Interactions