Fluconazole
Type of Medication: Antifungal
Indications: Oral or vaginal candidiasis. Line related sepsis
Side Effects: nausea, abdominal discomfort, diarrhoea, flatulence, headache, rash (discontinue treatment or monitor closely if infection invasive or systemic); less frequently dyspepsia, vomiting, taste disturbance, hepatic disorders, angioedema, anaphylaxis, dizziness, seizures, alopecia, pruritus, toxic epidermal necrolysis, Stevens-Johnson syndrome (severe cutaneous reactions more likely in AIDS patients), hyperlipidaemia, leucopenia, thrombocytopenia, and hypokalaemia reported
Route of administration: Adult (Intravenous)
Dose:400mg iv on day 1 then 200mg iv daily for 5 days
Administration: Infuse a 2mg/ml solution at a rate of 5-10ml/minute
Route of administration: Adult (Oral)
Dose:Vaginal candidiasis: 150mg stat. Oral candidiasis: 50mg daily for 7 to 14 days.
Route of administration: Paediatric (Intravenous)
Dose:6-12 mg/kg od
Administration:
Route of administration: Paediatric (Oral)
Dose:Oral candidiasis 3 mg/kg od. Loading dose 6 mg/kg may be used on first day to achieve steady state
Examples of some Drug Interactions
Interacting drug: Cisapride
arrythmias. AVOID.
Interacting drug: Cyclosporin
may increase levels. Monitor levels
Interacting drug: Midazolam
increased levels woth fluconazole
Interacting drug: Phenytoin
increased levels with phenytoin
Interacting drug: Rifampicin
decreased levels of fluconazole
Interacting drug: Sulphonylureas
prolonged serum half-life
Interacting drug: Tacrolimus
increases tacrolimus levels. Monitor
Interacting drug: Terfenadine
prolonged QT interval. AVOID.
Interacting drug: Theophylline
increases theophylline levels. Monitor for toxicity.
Interacting drug: Warfarin
increased INR