Type of Medication: Antibiotic
Indications: Treatment of community acquired pneumonia, cellulitis and surgical prophylaxis. Good activity against Haemophilus influenzae
Side Effects: Diarrhoea and vomiting, colitis, abdominal pain, headaches, hypersensitivity, erythema multiforme, abnormal liver function, cholestatic jaundice, eosinophilia, thrombocytopenia, leucopenia, agranulocytosis, aplastic anaemia, nephritis,confusion.
Route of administration: Adult (Intravenous)
Dose:750 mg tds. In more severe infections 1.5 g tds.
Administration: Dissolve in water and add to 50-100 ml saline. Infuse over 30 minutes. Can be given as a bolus (add 6 mls WFI to 750 mg vial or 15 mls to 1.5 g vial).
Route of administration: Adult (Oral)
Dose: As cefuroxime axetil: 250 mg twice daily, doubled for more serious infections.
Administration: Avaliable as 125 mg and 250 mg tablets, 125 mg/5 ml suspension and 125 mg sachets.
Route of administration: Paediatric (Intravenous)
Dose:60-100 mg/kg/day in 3 divided doses. Max:1.5g tds
Route of administration: Paediatric (Oral)
Dose: As cefuroxime axetil: child over 3 months 125 mg twice daily. Can be doubled in a child over 2 years with otitis media.
Examples of some Drug Interactions
Interacting drug: Probenecid
reduces excretion of cephalosporins
Interacting drug: Warfarin
Rare reports of increases in prothrombin time.