Pancreatin (Creon)

Type of Medication: Pancreatic enzyme

Indications: Pancreatic enzyme replacement

Side Effects: Nausea, vomiting, abdominal discomfort, diarrhoea, constipation; hyperuricosuria and hyperuricaemia have been associated with very high doses. Perioral skin and buccal irritation can occur if preperations retained in mouth. Excessive doses can cause perianal irritation.High strength enzymes such as Nutrizym 22 and Pancrease HL have been associated with large bowel strictures. Try and avoid > 10,000 units lipase/kg daily

Route of administration: Adult (Oral)

Dose:CREON 10,000. Start at 1 to 2 with meal. Aim to keep < 10,000 units lipase/Kg. (600 units protease, 10,000 units lipase, 8,000 units amylase per capsule)

Administration: Spread enzymes by taking some just before and during meal. Remember to take enzymes with fat containing snacks and to adjust according to fat content of food. Refer to dietitian

Route of administration: Adult (Oral)

Dose:CREON 25,000. As above but smaller dose required. Would not advise starting a new patient on creon 25,000. (1,000 units protease, 25,000 units lipase, 18,000 units amylase per capsule)

Administration:

Route of administration: Adult (Oral)

Dose:CREON 40,000. Each capsule contains lipase 40,000 PhEur units, amylase 25,000 PhEur units, Protease 1,600 PhEur units. Creon 40,000 should only be used if enzyme requirement is equal to or more than 40,000 lipase units per meal. The minimum effective dose should first be determined using lower strength pancreatic enzymes.

Administration:

Route of administration: Paediatric (Oral)

Dose: Infants: For every 120 mls of formula or breast milk give an initial dose of one quarter to one third of a capsule of creon 10,000. Increase dose gradually. See section on pancreatic enzymes for further information. Older Children. 1 to 2 capsules of creon 10,000 per meal and a half with snacks. See section on panceartic enzymes for further information

Administration:

Examples of some Drug Interactions