Piperacillin and tazobactam

Type of Medication: Antibiotic

Indications: Treatment of Pseudomonas aeruginosa and Burkholderia respiratory infections. Activity against H influenzae

Side Effects: Hypersensitivity reaction, haemolytic anaemia, nephritis erythema multiforme, Steven-Johnson syndrome, leucopenia, thrombocytopenia, paraesthesia, diarrhoea, colitis, hepatitis, cholestatic jaundice, increased LFT.

Route of administration: Adult (Intravenous)

Dose:Tazocin given as 4.5 gm tds

Administration: Tazocin can be diluted with 20 ml water and infused over 3 to 5 minutes or reconstituted in 50 ml saline and given over 30 minutes

Route of administration: Paediatric (Intravenous)

Route of administration: Paediatric (Intravenous)

Dose:300 mg/kg/day in 3-4 divided doses, max: 4g tds

Examples of some Drug Interactions

Interacting drug: Methotrexate –¬†increased risk of toxicity

Interacting drug: Muscle relaxants –¬†enhanced by piperacillin

Interacting drug: Probenecid – reduced piperacillin excretion