Sodium Fusidate

Type of Medication: Antibiotic

Indications: Treatment of Staph aureus. Used in combination with another anti-staph antibiotic to prevent emergence of resistance.

Side Effects: Gastrointestinal disturbances, reversible jaundice, rashes, blood disorders, acute renal faliure (usually with jaundice). Monitor liver function with high doses or with prolonged therapy. Elimination may be reduced in hepatic impairment or biliary dosease.

Route of administration: Adult (Intravenous)

Dose:over 50 kg: 500 mg every eight hours. under 50 kg and child: 6-7 mg/kg every eight hours

Administration: Must be reconsituted with buffer provided and diluted to 500 ml. If central venous line used infuse over 2 hours, if peripheral vein used infuse over 6 hours. Incompatible in solution of pH less than 7.4.

Route of administration: Adult (Oral)

Dose:Tablets as sodium fusidate: 500 mg every eight hours. May be doubled for severe infections

Administration: available as 250 mg sodium fusidate tablets

Route of administration: Adult (Oral)

Dose:Suspension as fusidic acid ; 750 mg every eight hours

Administration: available as 250 mg/5 ml fusidic acid suspension. Fusidic acid is incompletely absorbed and doses recommended for suspension are proportionately higher than those for sodium fusidate tablets.

Route of administration: Paediatric (Oral)

Dose:Suspension Child upto 1 year: 50 mg/kg daily ( in 3 divided doses); Child 1-5 yrs : 5 ml (250 mg) tds. Child 5-12 yrs; 10 ml (500 mg) tds

Examples of some Drug Interactions

Interacting drug: simvastatin, atorvastatin

possible increased risk of myopathy