Taurolidine
Type of Medication: Antibiotic
Indications: Taurolidine is an unlicensed product available as an intraperitoneal lavage (Taurolin®). It acts as an antibiotic and an anti-endotoxin with a broad spectrum of activity against Gram negative and positive bacteria and fungi. Taurolidine is active in vitro against P. aeruginosa and Burkholderia Cepacia Complex (Bcc). It is presently used as nebulised therapy in transplant patients with B.cepacia
Side Effects: Burning, hypersensitivity, bronchospasm
Route of administration: Adult (Nebulised)
Dose: Freeman hospital protocol – 2-3 ml of 2% solution twice daily
Administration: Must do a test dose as a significant number of patients get bronchospasm. 2 ml of 2% diluted with 2 ml sterile water with pre and post lung function
Examples of some Drug Interactions