Ticarcillin and clavulanic acid

Type of Medication: Antibiotic

Indications: Treatment of Pseudomonas aeruginosa and Burkholderia respiratory infections. Activity against H influenzae.

Side Effects: Nausea, vomiting, diarrhoea, colitis, coagulation disorders, heamorragic cystitis (more common in children), injection site reactions, Hypersensitivity reactions, haemolytic anaemia (rare), nephritis, erythema multiforme, Steven-Johnson syndrome, leucopenia, thrombocytopenia, confusion, hypokaleamia.

Route of administration: Adult (Intravenous)

Dose:3.2 g every 6-8 hourly (max 3.2 g every 4 hours)

Administration: Infuse over 30 to 40 minutes

Route of administration: Paediatric (Intravenous)

Dose:80 mg/ kg (max 3.2 g )every 6 to 8 hourly

Administration: Infuse over 30 to 40 minutes

Examples of some Drug Interactions

Interacting drug: Probenecid –┬áreduces excretion of penicillin